Her Story
About Diane
Diane Constantine is a healthcare informatics leader dedicated to advancing digital transformation and improving patient care through the strategic use of clinical technology. She currently serves as Senior Director of Enterprise Health Informatics at the Children’s Hospital of Philadelphia Children's Hospital of Philadelphia, where she leads initiatives that align technology systems with clinical and operational goals. Her work focuses on enhancing patient safety, improving clinician usability, and ensuring that healthcare technologies support evidence-based, high-quality care delivery.
She began her career as a bedside nurse, gaining extensive experience across pediatrics, surgery, ICU, transplant, and procedural care settings. This clinical foundation shaped her deep understanding of healthcare workflows and patient needs, which later guided her transition into clinical informatics. Over time, she advanced through roles in clinical systems, application management, and informatics leadership, including serving in executive-level and interim vice president positions. She also contributes to academia and professional development as adjunct faculty and a mentor for emerging informatics professionals.
In her leadership philosophy, Diane emphasizes collaboration, adaptability, and continuous learning. She is known for bridging clinical practice, operations, and technology by translating needs across disciplines and building alignment among stakeholders. A strong advocate for mentorship and workforce development, she actively supports the next generation of informatics leaders while championing the role of digital innovation in transforming healthcare delivery. Her academic and professional credentials include an MBA, MSN, RN, and NI-BC certification, reflecting her integrated expertise in nursing, business, and informatics.
Her Interview
Ten minutes with Diane
01What do you attribute your success to?
I attribute my success to watching my mother and aunt go through nursing school when I was in middle school and then watching them move through their careers - my mom became director of nursing education and my aunt became Associate Chief Nursing Officer. I found such inspiration in watching them. There have also been times when I wanted to achieve something and couldn't, and instead of cowering, it lit a fire in me. I would think, 'okay, so that didn't work, let's try this, let's take a step to the left.' That perseverance from experiences I had when I was young, where I didn't get something I thought I should get, has stayed with me through my whole career and served me very well. I'm also not afraid of ambiguity - I will put myself in a situation that I'm not entirely comfortable with and figure it out and learn from people around me. I don't have to have it all figured out, and I think that's another thing that helps with success.
02What’s the best career advice you’ve ever received?
The best career advice I ever received came from one of my mentors when I was in an interim role. I was struggling with imposter syndrome and asked her if I should change my signature to say 'interim' in the title. She just looked at me and said, 'What would a man do?' And I thought, oh, he would totally put it on there. But there I was, hemming and hawing about it. That simple question really stuck with me and helped me recognize how I was holding myself back.
03What advice would you give to young women entering your industry?
I think one of the most important things is that it's not really about what you necessarily want to do or what your passion is - you have to figure out what you're really good at. If I could give one piece of advice, it would be to really not limit yourself to what you see today. When I started as a bedside nurse, I never envisioned doing what I'm doing today. Your career evolves if you stay curious and stay open to new opportunities. I encourage women to focus less on having the perfect plan and just try to continuously learn, build relationships, and say yes to things that will help you grow. Your career is rarely linear, and some of the most rewarding chapters I've had have been where I've been willing to take a chance - sometimes that's been a lateral move, sometimes it's been a step down, not always an upward trajectory. Invest in your expertise from the beginning and invest in relationships throughout your entire career, because I think it's the expertise that helps open doors, but the relationships help create opportunities.
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