Jami M DeBrango-Palumbo, Chief Technical Operations Officer on Influential Women
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Influential Woman · Biotech Radiopharma

Jami M DeBrango-Palumbo

SHRM

Chief Technical Operations Officer, Nucleus RadioPharma

Carlsbad, CA 92009

32Years experience
1Article published
2Awards received

Certifications · Degrees · Memberships

Degree Massachusetts Institute of Technology - BioEngineering Degree London Business School - Roche Leadership Certification, Strategy and Leadership Degree UC San Diego - Rady School Of Management Degree The College of Saint Rose - Activities and societies: Political Science, Graphic Design, Voting Registration and Competitive Cheerleading (NCA/UCA) Cert Bioengineering Cert Change Management & Leadership Cert SHRM Member Healthcare Business Women's Association Member PDA (Parental Drug Association) Member MUSC Hollings Cancer Center advisory board Member San Diego Business Journal

True leadership is built on curiosity, embracing challenges, and focusing on building people, strengthening organizations, and improving patients' lives.

Jami M DeBrango-Palumbo · In Her Own Words

Her Story

About Jami

Jami DeBrango-Palumbo is a nationally recognized biotechnology executive whose career has been defined by building the infrastructure, operational capabilities, and leadership organizations that transform scientific innovation into life-changing therapies for patients. With more than 30 years of leadership experience, she has built and scaled compliant manufacturing operations, quality systems, and global organizations that consistently deliver breakthrough medicines safely, efficiently, right the first time, and with uncompromising quality.


As Chief Technical Operations Officer at Nucleus RadioPharma, Jami leads the company's national technical operations strategy, overseeing manufacturing, engineering, quality, supply chain, facilities, customer programs, IT, and process excellence. She is helping build a nationally integrated radiopharmaceutical manufacturing network designed to expand patient access to precision cancer therapies through standardized operations, scalable infrastructure, and operational excellence.


Her career uniquely spans nearly every major modality in modern biotechnology. Beginning at IDEC Pharmaceuticals and continuing through Biogen Idec, Genentech, Roche, Foundation Medicine Inc., and now Nucleus RadioPharma, she has led organizations across biologics, small molecules, molecular diagnostics, next-generation sequencing (NGS), and radiopharmaceuticals. She has built manufacturing capabilities, quality systems, and global operations that enable innovative therapies and diagnostics to reach patients safely, reliably, and efficiently while meeting the highest regulatory standards. Known for translating complex science into scalable operations, Jami is recognized as a transformational leader who combines operational discipline with a passion for people. She believes operational excellence means more than improving performance. It means creating organizations where quality is built into every process, continuous improvement drives efficiency and cost effectiveness, and employees are empowered to do their best work while never losing sight of the patient.


A lifelong learner who proudly describes herself as coming from the "school of hard knocks," Jami worked her way from human resources into technical operations and executive leadership by embracing every opportunity to learn, solve complex problems, and lead through change. She is passionate about mentoring the next generation of leaders and helping others realize their potential.


Jami is the founder of Strength In Heels®, a leadership platform dedicated to empowering professionals to lead with confidence, resilience, authenticity, and purpose. She is also the founder of SIH Consulting and co-founder of Kristin's Fund, a nonprofit organization established in honor of her sister-in-law to advance domestic violence prevention through education, awareness, and advocacy. She has served for more than a decade on the Advisory Board of the MUSC Hollings Cancer Center, supporting innovation in cancer research and patient care.


Her leadership has earned numerous professional honors, including recognition as a Healthcare Businesswomen's Association Rising Star and a San Diego Business Journal Leader of Influence in Life Sciences. She is also a contributing author to Women Living on Purpose, where she shares her perspective on resilience, authentic leadership, and building a legacy through service.


Outside of work, Jami enjoys gardening, hiking, yoga, cooking, traveling, and spending time with family and friends. She believes the true measure of leadership is not the title you hold, but the people you develop, the organizations you strengthen, and the patients whose lives are improved because of the work you do.

Her Interview

Ten minutes with Jami

01What do you attribute your success to?

I attribute my success to the two women who shaped my life from the very beginning: my mother and my grandmother. They were extraordinary examples of resilience, determination, and unwavering work ethic. Growing up, I watched them work two and sometimes three jobs while raising families, building businesses, and creating meaningful lives through perseverance and grit. They never viewed obstacles as limitations, only as challenges to overcome.

My grandmother, after her divorce, built her own catering business, and my mother founded and operated her own preschool. They taught me that success isn't defined by where you start or the titles you earn, but by your character, your willingness to work hard, and your courage to create opportunities where none exist. They instilled in me the confidence to believe that women can lead, build, innovate, and make a lasting impact.

Those lessons have guided every stage of my career. They taught me to lead with integrity, remain resilient through adversity, never stop learning, and invest in others along the way. More than any professional achievement, their example inspired my belief that true success is measured by the lives you positively influence, the people you help develop, and the legacy you leave behind.

02What’s the best career advice you’ve ever received?

The best career advice I have ever received came from a SVP in my early days at IDEC Pharma, during one of the most defining moments of my life. I was pregnant, questioning whether I should return to work, and struggling to balance my career with motherhood. She simply said, "If you're happy, the people around you will be happy."

Those words changed my perspective. I realized that pursuing a career I loved wasn't selfish. It allowed me to show up as the best version of myself for my family, my colleagues, and the people I had the privilege to lead. When you lead with purpose, passion, and authenticity, your energy becomes contagious.

That advice has stayed with me throughout my career. I've learned that success isn't about choosing between your personal life and your professional ambitions. It's about creating a life that aligns with your values, inspires those around you, and gives you the courage to lead authentically. When you are fulfilled, you have the capacity to lift others, create opportunity, and make a meaningful impact far beyond yourself.

03What advice would you give to young women entering your industry?

My advice to young women entering this industry is simple: be courageous enough to say "yes" before you feel completely ready. Growth rarely happens inside your comfort zone. Some of the greatest opportunities in my career came from taking on challenges I had never faced before and trusting that I could learn along the way.

Don't let imposter syndrome convince you that you don't belong. Every accomplished leader has faced moments of uncertainty. The difference is that they chose to move forward anyway. Believe in your ability to learn, adapt, and solve problems. Your perspective, your voice, and your contributions matter.

Be curious. Be resilient. Never stop learning. Find mentors who challenge you, invest in relationships, and remember to lift others as you climb. Success isn't about having all the answers. It's about having the courage to ask questions, embrace change, work hard, and continue growing.

Most importantly, never allow someone else to define your potential. The only limits that truly matter are the ones you place on yourself.


I always say, "just wear the heels."

04What are the biggest challenges or opportunities in your field right now?

One of the greatest challenges facing the radiopharmaceutical industry today is building the infrastructure required to translate scientific breakthroughs into routine patient care. Innovation is accelerating rapidly, but success depends on much more than developing a promising therapy. It requires a reliable isotope supply chain, standardized GMP manufacturing, robust quality systems, specialized engineering, efficient logistics, and a highly skilled workforce capable of delivering patient-specific therapies safely and consistently.


Because many radiopharmaceuticals have exceptionally short half-lives, every step, from isotope production and manufacturing to quality release, transportation, and patient administration, must operate with precision and speed. Expanding regional manufacturing capabilities and strengthening the domestic supply chain are essential to increasing patient access and ensuring these innovative therapies reach the people who need them.


At the same time, this rapidly growing field presents an extraordinary opportunity for the next generation of leaders. As the industry continues to evolve, there is tremendous demand for talented professionals in manufacturing, quality, engineering, technical operations, and supply chain who are passionate about building the future of precision medicine. The work is challenging, meaningful, and has the potential to directly improve, and even save patients' lives.

05What values are most important to you in your work and personal life?

The values that define my leadership are integrity, courage, loyalty, curiosity, and stewardship.

Integrity means having the courage to make the right decision, even when it is the hardest one. In highly regulated industries where every decision can ultimately impact a patient, there is no substitute for doing what's right.


I believe loyalty is often misunderstood. To me, loyalty isn't about avoiding difficult conversations or protecting the status quo. It's about being deeply committed to the mission, standing behind your people, challenging one another to be better, and leaving every organization stronger than you found it.

Curiosity has been one of the greatest drivers of my career. I didn't follow a traditional path into technical operations. I built my career by asking questions, stepping into unfamiliar roles, embracing change, and never believing that learning had an endpoint. That mindset continues to fuel both innovation and personal growth.

Finally, I believe leadership is stewardship. My responsibility is not simply to deliver results today, but to build sustainable organizations, develop future leaders, and create systems that continue to serve patients long after I'm gone. If the people I've mentored become better leaders, if the organizations I've helped build continue to thrive, and if more patients gain access to life-changing therapies because of the work we've done, then I've been successful.


For me, leadership isn't measured by the title you hold. It's measured by what you build, who you develop, and the legacy you leave behind.

Her Content Hub

Articles by Jami

A Chief Technical Operations Officer shares her unconventional journey from Human Resources to the executive suite, revealing how curiosity, courage, and a willingness to say yes transformed her career and life.

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